Question of the Week

October 7, 2020

Which of the following statements is true:

  • While Merkel cell polyomavirus (MCPyV) is implicated in many cases of Merkel cell carcinoma (MCC), it is estimated that 80 percent are caused primarily by UV-induced DNA mutations.
  • MCPyV integrates into the host genome in both non-lesional and lesional tissue of patients with MCC.
  • It is estimated that 80 percent of MCC in the northern hemisphere is due to MCPyV.
  • The incidence of MCC has remained relatively unchanged over the last 30 years.
  • Immune status and environmental factors have little influence in MCC.

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